The figures were released as an update by the department on the national TB incidence for Quarter 2 of 2012.
The report showed that to date this year, Wicklow has already been on the receiving end of over 200 reactors. This is out of just under 300 herds tested in total.
The average national reactor rate was 1.62 while Wicklow had as high as 6.90 in the West of the county, and 3.95 in the East.
Limerick county was the closest to Wicklow numbers, though they tested a drastically higher number of animals and herds.
To date there has been over 55,00 herds tested around the country and the next highest counties to feature are Dublin at 3.15, Wexford at 2.65 and Westmeath at 3.15.
The high count in Wicklow is put down to the high deer populations.
Deer are known to be carriers of the disease, and culling programmes are been organised to help stop the spread of the disease.